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The viral genome The SARS-CoV-2 genome is a 29.9-kb RNA that consists of 14 open reading frames (ORFs) encoding two large polyproteins (ORF1a and ORF1b) and 13 small ORFs that encode viral structural proteins and other polypeptides

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Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice

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Oxidative stress, viral infection, heat shock, nutrient deprivation, and alkylating agents all lead to activation of the cap-independent translation through IRES thus increasing the amount of Nrf2 [41, 42]